Friday, August 7, 2015

I Look Like an Engineer

This week tens of thousands of female engineers tweeted pictures of themselves and explanations of the work they do under the hashtag #ILookLikeAnEngineer. The movement made the front page of the New York Times, and so I decided to see what I could do with the tweets. Because this is a post about female engineers, I will describe the engineering steps in a little more detail:
  1. I used a program to scrape roughly 100,000 #ILookLikeAnEngineer tweets.
  2. From each tweet, I extracted any links to images, filtering out retweets and duplicate links.
  3. Using what Mark Zuckerberg in The Social Network would call “a little wget magic”, I downloaded all the pictures from the links. This gave me roughly 10,000 pictures (1.2 GB). Then I created a site so that drunken fraternity men could rate the attractiveness of the women...no, never mind.
  4. I programmatically cropped all 10,000 images into squares of uniform size.
  5. I wanted to see if I could create mosaics: compose a large image from tiled smaller images. There are websites which do this but I was pretty sure they would choke on 1.2 GB of pictures and not give me the freedom to experiment with parameters. The better solution was to write code to do it, and the lazier solution was to see if someone else had already done that, which they had. This allowed me to create mosaics using only one line of code, but I didn’t like the initial output so I added a bunch of my code to their code until it did what I wanted.

Here are the final results. From far away, the mosaics look like Seurat: for example, here is the woman who started it all.

Zoom in and you get lost in the individual pictures.

Here are some high resolution versions (warning: the files are large; zoom in). Please feel free to use them, with attribution, to persuade women to become engineers or do other socially useful things. (Do me a favor and let me know about it!)

I was working on this while watching the Republican debate, and at some point I got so tired of hearing overconfident men pretend to know more than they did. (The line that did me in was Huckabee’s assertion that scientists agree personhood begins at conception because of a fetus’s “DNA schedule”. What the hell is a DNA schedule?) So I went home and wrote code. I’m often comforted by the fact that, however loud and annoying the person lecturing me may be, they cannot get inside my skull: the silent sanctity of those few inches of space, the infinite freedom to reflect and create, remain my own.

And yet. It’s naive to think that freedom of thought is enough. My work requires a computer, which I need economic freedom to buy. And Huckabee’s proposed restrictions of contraception and abortion will reduce women’s economic freedom. My work is funded by government science agencies which Huckabee wants to cut.  So even code is cold comfort at the moment.

Apologies for the slightly bleak ending. If you have a custom image you’d like female-engineerified or higher resolution versions of these images, I’m happy to do that. If you are one of the women portrayed here and are uncomfortable having your face composed of many smaller women, let me know and I will take your picture down. And if you have ideas for cool things to do with this dataset or ways to improve the mosaics, please let me know! (Some pretty obvious improvements one could make are a) filtering out non-faces and b) filtering out duplicate images.)

Thursday, July 23, 2015

Advice and Sample Essays for Prospective Rhodes, Marshall, NSF, NDSEG, and Hertz Applicants

When applying for graduate scholarships, you have an advantage if you’re from a school that’s had many previous candidates: you can read decades of essays from successful applicants, be groomed by scholarship advisors, and so on. You’re also at an advantage if you happen to be good at networking, and can reach out to previous successful candidates.


Both these things seem unfair to me. In an attempt to level the playing field, in this post I’m providing two things: the essays I used to apply for scholarships and some tips. Obviously, I am not an expert and my experience is only one datapoint. This advice is specific to the scholarships named in the title, which I applied for and received; it may be applicable to other competitions as well. (I also applied for the Gates, which had a similar process, but withdrew my application when I decided to go to Oxford.) If you use the materials, please respect the fact that I am providing you with personal information for your benefit; do not plagiarize, redistribute or talk to me about my essays. If you have questions which are not answered here and which you think would be useful for many applicants to have answered, feel free to contact me and I will update this post if necessary! I am, unfortunately, probably not going to answer questions about specific applications.


Should I apply? I think the answer to this question varies by scholarship.


NSF, NDSEG, Hertz: these all give you funding to pursue a science PhD at a program of our choice. If you are applying to science grad schools, I would strongly recommend you apply if you have any chance of winning; they’re free money and prestige with no downside besides the time investment. To find out whether you would be a competitive applicant, I would a) read the criteria for the scholarship and b) talk to a professor in the sciences, your school’s scholarship office, or a previous applicant.
Marshall: funding for several years of study at an institution in the United Kingdom. Has a reputation for being more academic than the Rhodes; see this Wikipedia entry which I suspect is written by a Marshall Scholar. If you think you might conceivably be interested in studying in the UK and have a reasonably strong academic record (minimum undergraduate GPA is above 3.7), I would apply.


Rhodes: funding for several years of study at Oxford. Two things to understand (which I didn’t) when applying: a) if you win, you will be under strong pressure not to turn it down (unlike other scholarships, the Rhodes does not name alternates; I think this is silly, but that’s the way it is) and b) going to Oxford for a year or more can dramatically change your life. For example, I estimate that ⅔ of American Rhodes Scholars in long-distance relationships at the beginning of my year were not in relationships at the end. So try to actually imagine spending a year in Oxford; don’t just apply for the scholarship because it’s prestigious.


That said, I think the Rhodes is a wonderful experience, mostly because the other scholars are a diverse and passionate group and even if you’re somewhat antisocial like me you’ll probably make a lot of friends. (Update in the interest of balance: a 2014 Marshall Scholar tells me that the Marshall can also change your life and is well worth applying for.) Also, don’t be deterred from applying because:


  1. “the Rhodes is just for athletes” ~ this is no longer really true. I wrote on my resume that I did “long-distance hiking”, which was true but pretty lame.
  2. “the Rhodes isn’t for scientists” ~ silly for at least three reasons. i) there were lots of scientists in my year; ii) spending a year talking to non-scientists is arguably especially useful for scientists, because you’re probably going to spend the rest of your life surrounded by scientists; iii) many Rhodes scientists go on to do useful things precisely because they can communicate with non-scientists: see Leana Wen, Atul Gawande, Siddhartha Mukherjee, and Jonah Lehrer.
  3. “the Rhodes application involves a cocktail party” ~ it’s really not a big deal. There were no cocktails at mine.
Advice for all scholarships: if you’re not sure whether you have any chance, err on the side of applying. All scholarships are kind of a crapshoot, and it’s easy to get intimidated by profiles of the winners (I did).


Tips for essays:


a) start early. Some people start writing their Rhodes essays 6 months ahead of time (I started in July for the September deadline, but I also took ideas from writing I had done much earlier). Some candidates describe the essay-writing process as one of self-discovery: you decide what matters to you as you’re writing the essay. This takes time and multiple drafts.
b) most of the essays require you to both tell personal stories and detail your academic achievements. This combination made me uncomfortable (rereading my essays, I feel like a bit of an asshole) and you may feel the same way. It is okay to be honest about why you are an impressive candidate; just try not to sound too arrogant.
c) do not worry if you don’t have some inspiring personal story explaining why you care about what you study. Many successful candidates don’t. That said, if your academic and personal lives are entwined, by all means incorporate that. I would advise against including sad personal stories that aren’t actually deeply important to you, not just because it’s kind of a sleazy thing to do but also because it’s unlikely to be effective.


Tips for interviews:  


The Rhodes, Marshall, and Hertz involve interviews (the Hertz has two rounds).


a) It is normal to be unable to answer interview questions. This happened to me in both the Rhodes and Hertz interviews. Admit it, don’t bullshit, tell them what you do know, and don’t panic. I know successful candidates who thought their interviews were disastrous.
b) The thing that prepared me best for interviews was doing college debate, which trained me to give a concise and structured answer and then defend it. A good way to prep for interviews is to have debaters read your application and ask you questions -- or, if you are lucky enough not to know any debaters, smart, obnoxious, argumentative people. Old scholarship applicants are also good at doing practice interviews, which I recommend doing -- contact your school’s scholarship office to see if they will arrange them.
c) Read old interview questions to get a sense of what you’ll be facing. I provide a complete list of my interview questions in the Rhodes and Marshall folders; here are some Hertz interview questions. For the Hertz interview, I might recommend Randall Munroe’s What If? which speculates about what would occur in a bunch of implausible physical scenarios; see if you can figure them out without reading his answers. (In my Hertz interview, I was asked what would happen if a car with a helium balloon tied to the floor suddenly stopped on the highway. Another candidate was asked to name every way he could use common kitchen implements to distinguish between salt and sugar.) Google is your friend for practice interview questions.
d) Be prepared to defend everything in your application. Candidates who claim they spoke a foreign language have been addressed in that language. I was asked to recite an equation from a paper I wrote. Reread your application before your interview, and don’t claim achievements you can’t defend.
e) Get the small stuff right. Show up really early. Wear a suit. If you’re flying in for the interview, it’s probably worth it to fly in a day early if you can.
f) Prepare for each interview specifically. The Rhodes and Marshall will require knowledge of current events. The Rhodes interviewers may ask you about Cecil Rhodes, and the Marshall interviewers may ask you about George Marshall and the United Kingdom. The Hertz interviewers may ask you basic science questions in fields you claim to know about (I was a physics major, so I reviewed my quantum / statistical mechanics and electromagnetism notes. I told them I hadn’t taken chemistry since 10th grade, so they left me alone about that). Research your interviewers (you will often know their names) so you can tailor your answers to their level of knowledge. Prior to my final round Hertz interview, I wrote up a short statistical analysis of previous Hertz candidates and presented it to my interviewers.


Longer-term tips:


The New York Times tells me that people start preparing to apply for these scholarships freshman year. (I also like that article because it makes Harvard sound evil.) That is definitely not always true; certainly no one sent me the memo (although maybe Stanford does for some people). That said, winning any of these scholarships will require you to have done things before your senior year -- and those things are worth doing anyway. Specifically:


a) Get to know your professors. This helps in two ways. First, all these scholarships require at least 3 letters of recommendation (the Rhodes requires 5 - 8). Letters carry a lot of weight, and they should be from people who know you reasonably well -- getting an A in someone’s class is probably not sufficient. (I had done research or one-on-one work for most people who wrote my Rhodes recommendations.) Second, most professors are way smarter than their students. If you want to meet dazzling people who will help you learn a lot and do cool things, professors are good people to talk to.
b) Do things that you’ll probably fail at but will offer a large reward if you succeed, as long as there’s no downside to failure besides time and ego. Examples: try taking classes for which you lack the prerequisites, as long as you can drop the class if you’re clearly unprepared. Send your writing to publications which are likely to reject it. Reach out to people who are too important to talk to you. Do academic research. Apply for awards. Etc. You will not win these scholarships simply by having a good GPA.


Hopefully this was at least somewhat helpful and not hopelessly generic. If you have successfully applied for these scholarships and would like to contribute tips or essays, please let me know!

Other resources I found useful: see Phillip Guo and DJ Strouse on science fellowships and Alex Lang on the NSF. I did not find that much useful writing on the Marshall or Rhodes, but try Googling. Your school’s scholarship office, your professors, and past winners or applicants are all worth reaching out to.

Update:

Thanks to Talmo Pereira, an NSF winner who offers the following resources: 



And here are my application materials (2015): Research Plan - Personal Statement - Ratings Sheet"

Thanks also to a recent Marshall Scholar who wished to remain anonymous but who shared their interview questions; I have added them to the Dropbox folder with the requested caveat that "all interviews are different and this set of questions will not be representative of other experiences". 

Monday, June 29, 2015

What I Did This Year

My master’s thesis, which I spent most of this year working on with my supervisor, Chris Yau, contains 83 pages, 82 equations, and 13,000 lines of code, but because you are brilliant I am going to explain it here in 800 words (plus one 300-word note on what I learned from the project) and you are going to understand all of it.


The thesis develops better ways of performing two important statistical tasks on a widely used type of biological data. First I’ll explain the data, then I’ll explain the tasks, then I’ll explain what we did.


The data is called single-cell gene expression data. In a previous post I explained why we like gene expression data: it tells us how much RNA cells produce from their genes, which tells us which genes are important to the cell’s functions.


Before, we could only measure gene expression data by combining hundreds of cells: otherwise there wasn’t enough RNA to measure. But single-cell gene expression data lets us measure RNA levels within single cells. This is exciting because rather than pretending that all the cells in a tissue, or a tumor, are identical, we can look for groups of cells which are different in important ways. It’s like the difference between asking “What are Americans like on average?” and interviewing individual Americans. (We’re not all bad!)


These differences between cells matter because they have implications for how we treat disease. For example, single-cell analysis reveals that brain tumors which are classified as a single type in fact contain mixtures of multiple types of cells. And this diversity makes the tumors harder to treat: the more diverse the tumor is, the worse the patient’s prognosis, possibly because treatments that work on one group of cells don’t work well on the rest of the cells.


So people are writing papers saying single-cell data will “revolutionize” science. (I would write papers saying things like that, but no one pays attention to me.) Unfortunately, single-cell data is also hard for standard statistical models to deal with, because it has a lot of “zeros”: cells where we cannot detect any RNA produced from a gene. If you plot how much RNA is measured from a gene, it looks like this:
The spike at zero is bad because many statistical models assume data is Gaussian -- that is, it makes a nice blob, pictured below.


Obviously, the spike at zero in single-cell data makes the data very not Gaussian, and this makes it harder to perform many statistical tasks. Specifically, there are two things we often want to do with data -- cluster it, where we divide cells into groups so that similar cells are put into the same group, and reduce its dimension, where we plot cells in two (or more) dimensions such that similar cells appear close together [1]. Standard methods for performing these tasks assume the data is Gaussian.


In my thesis, we first develop a model for the patterns of zeros in single-cell data, and, based on this model, show that zeros really do hurt the performance of standard methods. We show, in several different datasets, that genes that are expressed at a higher level are less likely to be zero, and develop a model that describes this relationship. (I describe the mathematical details here [2].) Based on our model, we generate simulated data and show that the performance of standard statistical methods gets worse as we add zeros. Here’s a demo: move the slider to add zeros, and watch how the clusters (which are supposed to be separate) get mushed together. This is bad. We have an important new type of data; we have important statistical tasks that we often want to perform; standard methods for performing the tasks do not work well on the new data.


Diagnosing the problem is easy; how do we fix it? We develop two new models: a clustering model (ZIMM, for zero-inflated mixture model) and a dimensionality-reduction model (ZIFA, for zero-inflated factor analysis -- new statistical models are required to have a cool acronym). I give more details on how we developed the models in this footnote [3]. We show that our models do a better job than standard models on both simulated data and real biological data and put the code online so other people can use them. We are giving talks on the work at various venues, and a paper is under review. If you’re interested in using or extending these models, feel free to send me or Chris an email.


While we developed these models for single-cell data, they are potentially useful for lots of other datasets which have many zeros or missing datapoints. In the thesis we discuss several examples: recommendation datasets (how much will a person will like a product? -- see, for example, Netflix’s million dollar competition to predict movie ratings), usage datasets (how often a person will use a product?) and network datasets (how strongly are two nodes, eg airports, connected in a network?) Feel free to read the last chapter of the thesis and let me know if you have ideas for further applications (translation: do my homework for me).


Working on this project taught me about the role of luck in research. I often feel there’s a great deal of luck when you investigate some cool statistical hypothesis (“older women with cats are more likely to be single”). The hypothesis may or may not turn out to be true, but its truth doesn’t depend on how good a scientist you are. This luck evens out, though, because better scientists a) look at more things b) look at more interesting things c) look at them more rigorously.


You might think, though, that when you’re just doing math rather than observing the world, there’s no luck involved, only skill; equations are within your control. Still, my experience this year makes me feel there’s still luck involved, and I’ll draw an analogy to chess. Chess, in theory, is a game with no luck; there’s no dice, no drawn cards. But you will still hear chess players say “I got lucky” (or, more often, “I got unlucky”) because they calculated ten moves ahead, and on the eleventh move, their queen happened to be in the right place, and so they won, but they didn’t foresee it.


Similarly, my thesis involves about ten pages of algebra, at the end of which the math works out nicely. But I didn’t know this would happen when I began; this is what I mean by getting lucky.


Again, though, I feel the luck evens out here. I may occasionally beat a chessplayer who sees farther ahead than me because my pieces end up in the right place, but most of the time I’m going to lose. Similarly, I have met mathematicians who can see further down a proof tree than I can (and also have an eerie instinct for which branches will yield fruit) and they can prove trickier things than I can. In the case of my thesis, while we got “lucky” in the end, we also had to fix my screwups revise our approach several times; the final product feels like the result of a lot of blood, sweat, and tea [4]. Or maybe I’m just saying that so Oxford will let me graduate.


Notes:
[1] For each cell, we have data for tens of thousands of genes. It’s very hard to visualize or analyze data with ten thousand dimensions. So we want to reduce ten thousand to something more manageable, like two, in a way that preserves basic patterns in the data.
[2] Call the probability that a gene is zero p0, and the average expression of a gene when it’s not zero μ. Then, p0  = exp(-lambda*μ2), where exp is the exponential function and lambda is a parameter we fit to the data. Here are four different real biological datasets: the orange line is the actual data, and the red is our fitted model. You can see the orange line fits the red line pretty closely.


[3] Here’s a two-step procedure for developing statistical models:


  1. Write down (using math) the process you think generates the data. This is usually the straightforward part. In the case of ZIFA and ZIMM, our process is “generate data using a standard statistical model. Then, add zeros to that data”.
  2. Your model will have “parameters” -- numbers that affect the predictions it makes. For example, if your model is
    number_of_colleges_you_get_into = A*your_SAT_score + B*your_parents’_income
    then A and B are parameters of the model. Obviously, in order to calculate useful things with a model (in this case, how many colleges you are expected to get into) you need a way of figuring out the values of the parameters (for example, A = .01, B = .001). This is the hard part; it took me most of the winter.
[4] The British do not cry, or if they do, they cry Earl Grey.